Journal article
The Nicotinic α6-Subunit Selective Antagonist bPiDI Reduces Alcohol Self-Administration in Alcohol-Preferring Rats
J Srisontiyakul, HE Kastman, EV Krstew, P Govitrapong, AJ Lawrence
Neurochemical Research | SPRINGER/PLENUM PUBLISHERS | Published : 2016
Abstract
Cigarettes and alcohol are the most abused substances in the world and are commonly co-abused. Nicotine primarily acts in the brain on nicotinic acetylcholine receptors (nAChR), which are also a target for alcohol. The alpha6 subunit of nAChR is expressed almost exclusively in the brain reward system and may modulate the rewarding properties of alcohol and nicotine. Recently, N,N-decane-1,10-diyl-bis-3-picolinium diiodide (bPiDI) was synthesized as a selective, brain penetrant α6 subunit antagonist that reduces nicotine self-administration. The current study aimed to examine the effects of bPiDI on alcohol self-administration in inbred alcohol-preferring (iP) rats. Adult, male iP rats were t..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
This study was supported by the NHMRC Australia (Project Grant 628680), Royal Golden Jubilee PhD Program (PHD/0253/2552), Thailand Research Fund (DPG5780001), Mahidol University and a Committee for Aid and Education in Neurochemistry Grant (CAEN) from the International Society for Neurochemistry (ISN). AJL is a Fellow of the NHMRC (1020737). We also acknowledge the Victorian Government's Operational Infrastructure Support Program.